Analisis Derajat Pengembangan Hidrogel Komposit Polivinil Alkohol (PVA) Yang Dimuat Ekstrak Daun Kirinyuh (Eupatorium odoratum)
DOI:
https://doi.org/10.62775/edukasia.v5i1.1240Keywords:
Kirinyuh Leaves, Frezee-Thaw, Hydrogel, Polyvinyl Alcohol, Swelling DegreeAbstract
PVA/EDK (Kirinyuh/Eupatorium odoratum Leaves) composite hydrogel has been successfully developed using the freeze-thaw method. The precursor solution was prepared by dissolving PVA with a concentration of 12 wt% in water. Kirinyuh leaf extract solution (10 wt%) was then added to the precursor with a ratio of 10:0, 10:1, 10:2, and 10:3. The composite hydrogel was then fabricated using the freeze-thaw method and then the characteristics of the swelling degree and density were investigated. The purpose of this study was to explore the swelling degree of the Polyvinyl Alcohol (PVA) Composite hydrogel loaded with Kirinyuh Leaf Extract (Eupatorium odoratum). The research method used in this paper is a quantitative approach. The results showed that the density of the resulting hydrogel decreased with the addition of EDK mass, while the swelling degree increased with the increase in EDK mass. PVA hydrogel has an expansion degree of (187.05±7.36) %, while the expansion degree of composite hydrogel for PVA:EDK ratio (10:1), (10:2), and (10:3) is (209.60±30.90) %, (219.73±13.72) %, and (231.11±15.03) %. These results indicate that the degree of expansion of the PVA/EDK hydrogel produced has met the requirements for use as a wound dressing. However, for further development, further tests are needed such as tensile tests, porosity tests, morphology tests and antibacterial tests of the hydrogel for further applications.
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References
de Albuquerque, Tiago Lima, Victor Gabriel Cunha Cavalcante, Weslley da Silva Rocha, André Casimiro de Macedo, and Maria Valderez Ponte Rocha. 2024. “Hydrogels Based on Lignin Extracted from Cashew Apple Bagasse and Its Application in Antimicrobial Wound Dressings.” International Journal of Biological Macromolecules 262:130169. doi: https:/doi.org/10.1016/j.ijbiomac.2024.130169.
Asy-Syifa, Nabila, Kusjuriansah, William Xaveriano Waresindo, Dhewa Edikresnha, Tri Suciati, and Khairurrijal Khairurrijal. 2022. “The Study of the Swelling Degree of the PVA Hydrogel with Varying Concentrations of PVA.” Journal of Physics: Conference Series 2243(1). doi: 10.1088/1742-6596/2243/1/012053.
Darmayanti, Agung Sri, and Sri Wuryanti. 2010. “Inventarisasi Tumbuhan Berkhasiat Obat Di Wilayah Desa Egon, Kecamatan Waegete, Kabupaten Sikka Nusa Tenggara Timur.” Berk. Penel. Hayati 4:5–11.
Eldeeb, Alaa Emad, Salwa Salah, and Nermeen A. Elkasabgy. 2022. “Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review.” AAPS PharmSciTech 23(7). doi: 10.1208/s12249-022-02419-1.
Firlar, Ilayda, Mine Altunbek, Colleen McCarthy, Murugan Ramalingam, and Gulden Camci-Unal. 2022. “Functional Hydrogels for Treatment of Chronic Wounds.” Gels 8(2):1–23. doi: 10.3390/gels8020127.
Ghani, Afsaneh, Ehsan Nazarzadeh Zare, Pooyan Makvandi, and Navid Rabiee. 2024. “Antioxidant, Antibacterial and Biodegradable Hydrogel Films from Carboxymethyl Tragacanth Gum and Clove Extract: Potential for Wound Dressings Application.” Carbohydrate Polymer Technologies and Applications 7:100428. doi: https:/doi.org/10.1016/j.carpta.2024.100428.
Hasan, Md Mahmudul, Md Forhad Uddin, Nayera Zabin, Md Salman Shakil, Morshed Alam, Fahima Jahan Achal, Most Hosney Ara Begum, Md Sakib Hossen, Md Ashraful Hasan, and Md Mahbubul Morshed. 2021. “Fabrication and Characterization of Chitosan-Polyethylene Glycol (Ch-Peg) Based Hydrogels and Evaluation of Their Potency in Rat Skin Wound Model.” International Journal of Biomaterials 2021:1–11. doi: 10.1155/2021/4877344.
Julaeha, Euis, Winda Rian Puspita, Nandang Permadi, Asep Harja, Sarifah Nurjanah, Tatang Wahyudi, and Jamaludin Al-Anshori. 2024. “Optimization of Citrus Aurantifolia Peel Extract Encapsulation in Alginate-Gelatin Hydrogel Microbeads for Antibacterial Wound Dressing Applications.” Carbohydrate Polymer Technologies and Applications 7:100406. doi: https:/doi.org/10.1016/j.carpta.2023.100406.
Kopač, Tilen, Aleš Ručigaj, and Matjaž Krajnc. 2020. “The Mutual Effect of the Crosslinker and Biopolymer Concentration on the Desired Hydrogel Properties.” International Journal of Biological Macromolecules 159:557–69. doi: 10.1016/j.ijbiomac.2020.05.088.
Kusjuriansah, Kusjuriansah, Marathur Rodhiyah, Nabila Asy Syifa, Halida Rahmi Luthfianti, William Xaveriano Waresindo, Dian Ahmad Hapidin, Tri Suciati, Dhewa Edikresnha, and Khairurrijal Khairurrijal. 2023. “Composite Hydrogel of Poly(Vinyl Alcohol) Loaded by Citrus Hystrix Leaf Extract, Chitosan, and Sodium Alginate with In Vitro Antibacterial and Release Test.” ACS Omega (March). doi: 10.1021/acsomega.3c10143.
Lanur, Helena, and Oktavius Yoseph Tuta Mago. 2018. “Eksplorasi Tumbuhan Obat Tradisional Desa Blata Tatin Kecamatan Kangae Kabupaten Sikka.” Jurnal Saintek Lahan Kering 1(2):24–25. doi: 10.32938/slk.v1i2.526.
Latiffah, Efa, Asti Sawitri, Bertolomeus Haryanto Agung, Dian Ahmad Hapidin, Dhewa Edikresnha, Elfahmi Elfahmi, and Khairurrijal Khairurrijal. 2024. “Antibacterial Activity of Electrospun Nanofibers Polyvinylpyrrolidone/Cellulose Acetate Matrix Loaded by Ageratum Conyzoides L. Weed.” Case Studies in Chemical and Environmental Engineering 9:100651. doi: https:/doi.org/10.1016/j.cscee.2024.100651.
Li, Xiaowei, Brian Cho, Russell Martin, Michelle Seu, Chi Zhang, Zhengbing Zhou, Ji Suk Choi, Xuesong Jiang, Long Chen, Gurjot Walia, Jerry Yan, Megan Callanan, Huanhuan Liu, Kevin Colbert, Justin Morrissette-McAlmon, Warren Grayson, Sashank Reddy, Justin M. Sacks, and Hai Quan Mao. 2019. “Nanofiber-Hydrogel Composite–Mediated Angiogenesis for Soft Tissue Reconstruction.” Science Translational Medicine 11(490):1–12. doi: 10.1126/scitranslmed.aau6210.
Ma, Shuaijiang, Shiwei Wang, Qian Li, Yuting Leng, Lianhui Wang, and Guo-Hua Hu. 2017. “A Novel Method for Preparing Poly(Vinyl Alcohol) Hydrogels: Preparation, Characterization, and Application.” Industrial & Engineering Chemistry Research 56(28):7971–76. doi: 10.1021/acs.iecr.7b01812.
Morgado, Patrícia I., Ana Aguiar-Ricardo, and Ilídio J. Correia. 2015. “Asymmetric Membranes as Ideal Wound Dressings: An Overview on Production Methods, Structure, Properties and Performance Relationship.” Journal of Membrane Science 490:139–51. doi: 10.1016/j.memsci.2015.04.064.
Peng, Shuijiao, Shuxuan Liu, Yujun Sun, Nanping Xiang, Xiancai Jiang, and Linxi Hou. 2018. “Facile Preparation and Characterization of Poly(Vinyl Alcohol)--Glycerol Supramolecular Hydrogel Electrolyte.” European Polymer Journal 106(June):206–13. doi: 10.1016/j.eurpolymj.2018.07.024.
Putry, B, O., Harfiani E, and S. Tjang Y. 2021. “Systematic Review : Efektivitas Ekstrak Daun Kirinyuh ( Chromolaena Odorata ) Terhadap Penyembuhan Luka Studi In Vivo Dan In Vitro.” Seminar Nasional Riset Kedokteran (Sensorik Ii):1–13.
Waresindo, William Xaveriano, Halida Rahmi Luthfianti, Dhewa Edikresnha, Tri Suciati, Fatimah Arofiati Noor, and Khairurrijal Khairurrijal. 2021. “A Freeze–Thaw PVA Hydrogel Loaded with Guava Leaf Extract: Physical and Antibacterial Properties.” RSC Advances 11(48):30156–71. doi: 10.1039/D1RA04092H.
Wulandari, Linda, and Khotibul Umam. 2023. “Potensi Ekstrak Daun Kirinyuh (Chromolaena Odorata) Dalam Menghambat Bakteri Patogen (E. Sakazakii, S. Typi, Dan L. Monocytogenes).” Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) 8(2):18–31. doi: 10.33474/e-jbst.v8i2.497.
Yassir, Muhammad, and Asnah Asnah. 2019. “Pemanfaatan Jenis Tumbuhan Obat Tradisional Di Desa Batu Hamparan Kabupaten Aceh Tenggara.” BIOTIK: Jurnal Ilmiah Biologi Teknologi Dan Kependidikan 6(1):17. doi: 10.22373/biotik.v6i1.4039.
Asy-Syifa, Nabila, Kusjuriansah, William Xaveriano Waresindo, Dhewa Edikresnha, Tri Suciati, and Khairurrijal Khairurrijal. 2022. “The Study of the Swelling Degree of the PVA Hydrogel with Varying Concentrations of PVA.” Journal of Physics: Conference Series 2243(1). doi: 10.1088/1742-6596/2243/1/012053.
Darmayanti, Agung Sri, and Sri Wuryanti. 2010. “Inventarisasi Tumbuhan Berkhasiat Obat Di Wilayah Desa Egon, Kecamatan Waegete, Kabupaten Sikka Nusa Tenggara Timur.” Berk. Penel. Hayati 4:5–11.
Eldeeb, Alaa Emad, Salwa Salah, and Nermeen A. Elkasabgy. 2022. “Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review.” AAPS PharmSciTech 23(7). doi: 10.1208/s12249-022-02419-1.
Firlar, Ilayda, Mine Altunbek, Colleen McCarthy, Murugan Ramalingam, and Gulden Camci-Unal. 2022. “Functional Hydrogels for Treatment of Chronic Wounds.” Gels 8(2):1–23. doi: 10.3390/gels8020127.
Ghani, Afsaneh, Ehsan Nazarzadeh Zare, Pooyan Makvandi, and Navid Rabiee. 2024. “Antioxidant, Antibacterial and Biodegradable Hydrogel Films from Carboxymethyl Tragacanth Gum and Clove Extract: Potential for Wound Dressings Application.” Carbohydrate Polymer Technologies and Applications 7:100428. doi: https:/doi.org/10.1016/j.carpta.2024.100428.
Hasan, Md Mahmudul, Md Forhad Uddin, Nayera Zabin, Md Salman Shakil, Morshed Alam, Fahima Jahan Achal, Most Hosney Ara Begum, Md Sakib Hossen, Md Ashraful Hasan, and Md Mahbubul Morshed. 2021. “Fabrication and Characterization of Chitosan-Polyethylene Glycol (Ch-Peg) Based Hydrogels and Evaluation of Their Potency in Rat Skin Wound Model.” International Journal of Biomaterials 2021:1–11. doi: 10.1155/2021/4877344.
Julaeha, Euis, Winda Rian Puspita, Nandang Permadi, Asep Harja, Sarifah Nurjanah, Tatang Wahyudi, and Jamaludin Al-Anshori. 2024. “Optimization of Citrus Aurantifolia Peel Extract Encapsulation in Alginate-Gelatin Hydrogel Microbeads for Antibacterial Wound Dressing Applications.” Carbohydrate Polymer Technologies and Applications 7:100406. doi: https:/doi.org/10.1016/j.carpta.2023.100406.
Kopač, Tilen, Aleš Ručigaj, and Matjaž Krajnc. 2020. “The Mutual Effect of the Crosslinker and Biopolymer Concentration on the Desired Hydrogel Properties.” International Journal of Biological Macromolecules 159:557–69. doi: 10.1016/j.ijbiomac.2020.05.088.
Kusjuriansah, Kusjuriansah, Marathur Rodhiyah, Nabila Asy Syifa, Halida Rahmi Luthfianti, William Xaveriano Waresindo, Dian Ahmad Hapidin, Tri Suciati, Dhewa Edikresnha, and Khairurrijal Khairurrijal. 2023. “Composite Hydrogel of Poly(Vinyl Alcohol) Loaded by Citrus Hystrix Leaf Extract, Chitosan, and Sodium Alginate with In Vitro Antibacterial and Release Test.” ACS Omega (March). doi: 10.1021/acsomega.3c10143.
Lanur, Helena, and Oktavius Yoseph Tuta Mago. 2018. “Eksplorasi Tumbuhan Obat Tradisional Desa Blata Tatin Kecamatan Kangae Kabupaten Sikka.” Jurnal Saintek Lahan Kering 1(2):24–25. doi: 10.32938/slk.v1i2.526.
Latiffah, Efa, Asti Sawitri, Bertolomeus Haryanto Agung, Dian Ahmad Hapidin, Dhewa Edikresnha, Elfahmi Elfahmi, and Khairurrijal Khairurrijal. 2024. “Antibacterial Activity of Electrospun Nanofibers Polyvinylpyrrolidone/Cellulose Acetate Matrix Loaded by Ageratum Conyzoides L. Weed.” Case Studies in Chemical and Environmental Engineering 9:100651. doi: https:/doi.org/10.1016/j.cscee.2024.100651.
Li, Xiaowei, Brian Cho, Russell Martin, Michelle Seu, Chi Zhang, Zhengbing Zhou, Ji Suk Choi, Xuesong Jiang, Long Chen, Gurjot Walia, Jerry Yan, Megan Callanan, Huanhuan Liu, Kevin Colbert, Justin Morrissette-McAlmon, Warren Grayson, Sashank Reddy, Justin M. Sacks, and Hai Quan Mao. 2019. “Nanofiber-Hydrogel Composite–Mediated Angiogenesis for Soft Tissue Reconstruction.” Science Translational Medicine 11(490):1–12. doi: 10.1126/scitranslmed.aau6210.
Ma, Shuaijiang, Shiwei Wang, Qian Li, Yuting Leng, Lianhui Wang, and Guo-Hua Hu. 2017. “A Novel Method for Preparing Poly(Vinyl Alcohol) Hydrogels: Preparation, Characterization, and Application.” Industrial & Engineering Chemistry Research 56(28):7971–76. doi: 10.1021/acs.iecr.7b01812.
Morgado, Patrícia I., Ana Aguiar-Ricardo, and Ilídio J. Correia. 2015. “Asymmetric Membranes as Ideal Wound Dressings: An Overview on Production Methods, Structure, Properties and Performance Relationship.” Journal of Membrane Science 490:139–51. doi: 10.1016/j.memsci.2015.04.064.
Peng, Shuijiao, Shuxuan Liu, Yujun Sun, Nanping Xiang, Xiancai Jiang, and Linxi Hou. 2018. “Facile Preparation and Characterization of Poly(Vinyl Alcohol)--Glycerol Supramolecular Hydrogel Electrolyte.” European Polymer Journal 106(June):206–13. doi: 10.1016/j.eurpolymj.2018.07.024.
Putry, B, O., Harfiani E, and S. Tjang Y. 2021. “Systematic Review : Efektivitas Ekstrak Daun Kirinyuh ( Chromolaena Odorata ) Terhadap Penyembuhan Luka Studi In Vivo Dan In Vitro.” Seminar Nasional Riset Kedokteran (Sensorik Ii):1–13.
Waresindo, William Xaveriano, Halida Rahmi Luthfianti, Dhewa Edikresnha, Tri Suciati, Fatimah Arofiati Noor, and Khairurrijal Khairurrijal. 2021. “A Freeze–Thaw PVA Hydrogel Loaded with Guava Leaf Extract: Physical and Antibacterial Properties.” RSC Advances 11(48):30156–71. doi: 10.1039/D1RA04092H.
Wulandari, Linda, and Khotibul Umam. 2023. “Potensi Ekstrak Daun Kirinyuh (Chromolaena Odorata) Dalam Menghambat Bakteri Patogen (E. Sakazakii, S. Typi, Dan L. Monocytogenes).” Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) 8(2):18–31. doi: 10.33474/e-jbst.v8i2.497.
Yassir, Muhammad, and Asnah Asnah. 2019. “Pemanfaatan Jenis Tumbuhan Obat Tradisional Di Desa Batu Hamparan Kabupaten Aceh Tenggara.” BIOTIK: Jurnal Ilmiah Biologi Teknologi Dan Kependidikan 6(1):17. doi: 10.22373/biotik.v6i1.4039.
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Published
2024-12-19
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How to Cite
Analisis Derajat Pengembangan Hidrogel Komposit Polivinil Alkohol (PVA) Yang Dimuat Ekstrak Daun Kirinyuh (Eupatorium odoratum). (2024). EDUKASIA Jurnal Pendidikan Dan Pembelajaran, 5(1), 2253-2260. https://doi.org/10.62775/edukasia.v5i1.1240
